Lipotoxicity in Kidney, Heart, and Skeletal Muscle Dysfunction
نویسندگان
چکیده
منابع مشابه
Lipotoxicity in cardiac and skeletal muscle
Lipotoxicity is defined as the untoward consequences of the accumulation of excess lipid in non-adipose tissue. Fatty acids are an important substrate for myocyte metabolism, yet mismatch of cellular uptake and utilization results in lipid accumulation that is clearly detrimental. Within the myocyte, lipotoxicity can lead to cellular dysfunction, resulting in defective contraction or relaxation...
متن کاملVascular metabolic dysfunction and lipotoxicity.
The purpose of this study was to determine the role of lipotoxicity in vascular smooth muscle (VSM). C(1)-BODIPY 500/510 C(12) used to assess the ability of VSM A7r5 cells to transport long-chain fatty acids showed that lipid transport did not appear to limit metabolism. Thin layer chromatography revealed that storage of transported fatty acid occurred primarily as mono- and diglycerides and fa...
متن کاملLipotoxicity in the heart.
Cardiomyopathy is associated with both rare genetic metabolic abnormalities and highly prevalent diseases characterized by elevated serum triglycerides and nonesterified fatty acids, such as obesity and type 2 diabetes. In these disorders, an imbalance between fatty acid uptake and utilization leads to the inappropriate accumulation of free fatty acids and neutral lipids within cardiomyocytes. ...
متن کاملSkeletal muscle mitochondrial dysfunction & diabetes.
Skeletal muscle insulin resistance is a key contributor to the pathophysiology of type 2 diabetes. Recent studies have shown that insulin resistance in a variety of conditions including type 2 diabetes, ageing and in offspring of type 2 diabetes is associated with muscle mitochondrial dysfunction. The important question is whether insulin resistance results from muscle mitochondrial dysfunction...
متن کاملSkeletal muscle molecular alterations precede whole-muscle dysfunction in NYHA Class II heart failure patients
BACKGROUND Heart failure (HF), a debilitating disease in a growing number of adults, exerts structural and neurohormonal changes in both cardiac and skeletal muscles. However, these alterations and their affected molecular pathways remain uncharacterized. Disease progression is known to transform skeletal muscle fiber composition by unknown mechanisms. In addition, perturbation of specific horm...
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ژورنال
عنوان ژورنال: Nutrients
سال: 2019
ISSN: 2072-6643
DOI: 10.3390/nu11071664